2012/13 influenza vaccine effectiveness against hospitalised influenza A(H1N1)pdm09, A(H3N2) and B: estimates from a European network of hospitals.
Identifieur interne : 000085 ( France/Analysis ); précédent : 000084; suivant : 0000862012/13 influenza vaccine effectiveness against hospitalised influenza A(H1N1)pdm09, A(H3N2) and B: estimates from a European network of hospitals.
Auteurs : M. Rondy [France] ; O. Launay [France] ; J. Puig-Barberà ; G. Gefenaite ; J. Castilla ; K. De Gaetano Donati ; F. Galtier [France] ; E. Hak ; M. Guevara ; S. Costanzo ; A. Moren [France]Source :
- Eurosurveillance [ 1560-7917 ] ; 2015-01-15.
Abstract
While influenza vaccines aim to decrease the incidence of severe influenza among high-risk groups, evidence of influenza vaccine effectiveness (IVE) among the influenza vaccine target population is sparse. We conducted a multicentre test-negative case-control study to estimate IVE against hospitalised laboratory-confirmed influenza in the target population in 18 hospitals in France, Italy, Lithuania and the Navarre and Valencia regions in Spain. All hospitalised patients aged ≥18 years, belonging to the target population presenting with influenza-like illness symptom onset within seven days were swabbed. Patients positive by reverse transcription polymerase chain reaction for influenza virus were cases and those negative were controls. Using logistic regression, we calculated IVE for each influenza virus subtype and adjusted it for month of symptom onset, study site, age and chronic conditions. Of the 1,972 patients included, 116 were positive for influenza A(H1N1)pdm09, 58 for A(H3N2) and 232 for influenza B. Adjusted IVE was 21.3% (95% confidence interval (CI): -25.2 to 50.6; n=1,628), 61.8% (95% CI: 26.8 to 80.0; n=557) and 43.1% (95% CI: 21.2 to 58.9; n=1,526) against influenza A(H1N1) pdm09, A(H3N2) and B respectively. Our results suggest that the 2012/13 IVE was moderate against influenza A(H3N2) and B and low against influenza A(H1N1) pdm09.
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Galtier</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-232778" status="INCOMING"> <orgName>REseau national d'Investigation clinique en VACcinologie</orgName> <orgName type="acronym">REIVAC</orgName> <desc> <address> <addrLine>Bâtiment Lavoisier - 27, rue du Faubourg Saint Jacques - 75014 PARIS</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-356457" type="direct"></relation> <relation active="#struct-303623" type="direct"></relation> <relation active="#struct-302361" type="direct"></relation> <relation active="#struct-300142" type="direct"></relation> <relation active="#struct-300123" type="direct"></relation> <relation active="#struct-300068" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-356457" type="direct"><org type="institution" xml:id="struct-356457" status="INCOMING"> <orgName>Centre National de Gestion des Essais de Produits de Santé (CeNGEPS)</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-302361" type="direct"><org type="institution" xml:id="struct-302361" status="VALID"> <orgName>Groupe hospitalier Broca</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300142" type="direct"><org type="institution" xml:id="struct-300142" status="VALID"> <orgName>Hôtel-Dieu</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300123" type="direct"><org type="institution" xml:id="struct-300123" status="VALID"> <orgName>CHU Cochin [AP-HP]</orgName> <desc> <address> <addrLine>27 Rue du Faubourg Saint-Jacques 75014 Paris</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Hak, E" sort="Hak, E" uniqKey="Hak E" first="E" last="Hak">E. Hak</name></author><author><name sortKey="Guevara, M" sort="Guevara, M" uniqKey="Guevara M" first="M." last="Guevara">M. Guevara</name></author><author><name sortKey="Costanzo, S" sort="Costanzo, S" uniqKey="Costanzo S" first="S" last="Costanzo">S. Costanzo</name></author><author><name sortKey="Moren, A" sort="Moren, A" uniqKey="Moren A" first="A" last="Moren">A. Moren</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-534644" status="INCOMING"> <orgName>EpiConcept [Paris]</orgName> <desc> <address> <addrLine>Paris.</addrLine> <country key="FR"></country> </address> </desc> </hal:affiliation><country>France</country></affiliation></author></analytic><series><title level="j">Eurosurveillance</title><idno type="ISSN">1560-7917</idno><imprint><date type="datePub">2015-01-15</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>While influenza vaccines aim to decrease the incidence of severe influenza among high-risk groups, evidence of influenza vaccine effectiveness (IVE) among the influenza vaccine target population is sparse. We conducted a multicentre test-negative case-control study to estimate IVE against hospitalised laboratory-confirmed influenza in the target population in 18 hospitals in France, Italy, Lithuania and the Navarre and Valencia regions in Spain. All hospitalised patients aged ≥18 years, belonging to the target population presenting with influenza-like illness symptom onset within seven days were swabbed. Patients positive by reverse transcription polymerase chain reaction for influenza virus were cases and those negative were controls. Using logistic regression, we calculated IVE for each influenza virus subtype and adjusted it for month of symptom onset, study site, age and chronic conditions. Of the 1,972 patients included, 116 were positive for influenza A(H1N1)pdm09, 58 for A(H3N2) and 232 for influenza B. Adjusted IVE was 21.3% (95% confidence interval (CI): -25.2 to 50.6; n=1,628), 61.8% (95% CI: 26.8 to 80.0; n=557) and 43.1% (95% CI: 21.2 to 58.9; n=1,526) against influenza A(H1N1) pdm09, A(H3N2) and B respectively. Our results suggest that the 2012/13 IVE was moderate against influenza A(H3N2) and B and low against influenza A(H1N1) pdm09.</p> </div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><noCountry><name sortKey="Castilla, J" sort="Castilla, J" uniqKey="Castilla J" first="J" last="Castilla">J. Castilla</name><name sortKey="Costanzo, S" sort="Costanzo, S" uniqKey="Costanzo S" first="S" last="Costanzo">S. Costanzo</name><name sortKey="De Gaetano Donati, K" sort="De Gaetano Donati, K" uniqKey="De Gaetano Donati K" first="K" last="De Gaetano Donati">K. De Gaetano Donati</name><name sortKey="Gefenaite, G" sort="Gefenaite, G" uniqKey="Gefenaite G" first="G" last="Gefenaite">G. Gefenaite</name><name sortKey="Guevara, M" sort="Guevara, M" uniqKey="Guevara M" first="M." last="Guevara">M. Guevara</name><name sortKey="Hak, E" sort="Hak, E" uniqKey="Hak E" first="E" last="Hak">E. Hak</name><name sortKey="Puig Barbera, J" sort="Puig Barbera, J" uniqKey="Puig Barbera J" first="J" last="Puig-Barberà">J. Puig-Barberà</name></noCountry><country name="France"><noRegion><name sortKey="Rondy, M" sort="Rondy, M" uniqKey="Rondy M" first="M" last="Rondy">M. Rondy</name></noRegion><name sortKey="Galtier, F" sort="Galtier, F" uniqKey="Galtier F" first="F." last="Galtier">F. Galtier</name><name sortKey="Launay, O" sort="Launay, O" uniqKey="Launay O" first="O." last="Launay">O. Launay</name><name sortKey="Moren, A" sort="Moren, A" uniqKey="Moren A" first="A" last="Moren">A. Moren</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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